@lohan997 Did you try other baud rates using XLoader? (they are not used for T2Laser which uses 57600 for firmware update)
Eleks Mana changed from using a real Atmel microcontroller to some Chinese version which in my experience has memory and over heating problems. I have several Mana boards but toss the supplied Nano and replace it with one of these better brands:
They all use genuine ATmega328p chips but instead of the real FTDI FT232 they use a Chinese UART (the CH340) but that seems to work OK.
You can get the Geekcreit brand from Banggood for a few dollars, or buy the genuine Arduino. If you work a lot with Arduino devices I recommend getting an AVR programmer, they are very cheap and will let you install the boot loader or install firmware without a boot loader for faster startup.
If you can't upload with XLoader or Arduino IDE you probably have a dead Nano. The AVR programmer may be able to fix it.
@Belarch-1 The connect speed (baud rate) for Grbl 0.9 and higher is 115200 but he is attempting to upload firmware so the correct speed is determined by the boot loader that is currently installed, usually 57600 but may be lower 19200 or even 9600.